Latex Extract Of Jackfruit (artocarpus Integrifolia) Has Anti-cancer Property As Checked On Mcf-7 Human Breast Cancer Cell Line
Abstract Category: Science
Course / Degree: D.Phil
Institution / University: Allahabad University, India
Published in: 2013
The objective of the present study was to evaluate the in-vitro anti- cancer effects of methanolic extract of jackfruit (Artocarpus integrifolia) latex against MCF-7 human breast cancer cell lines by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) method. The assay provides a convenient, sensitive, quantitative and reliable assay for determining the cytotoxic activity of test sample. The activity was evaluated at different concentration (100 µg, 250 µg, 500µg, 1000µg) of test material. Human breast cancer cell line MCF-7 was taken to see the cytotoxic activity of latex extract. Extract were added in different concentration from 100 µg, 500 µg, 750 µg, 1000 µg to MCF-7 Human breast cancer cell line. Twenty-four-hour exposure to Artocarpus integrifolia extract inhibits cell proliferation as compared with untreatedcell. Growth Inhibition was noted 68.3 %, 74.4 %, 77.5 %, 79.9 % against the concentration 100 µg, 500 µg, 750 µg, 1000 µg of test sample respectively. Our results indicate that the plant has a promising anti-cancer activity. Further investigation for active compound present in Artocarpus integrifolia required for cancer management and for the development of new anti- cancer drugs
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Submission Details: Paper Abstract submitted by ekta prakash from India on 15-Apr-2013 16:39.
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