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Cytotoxic Activities Of Ethanolic Extracts Of Medicinal Plants Of Euphorbiacae Family Studied On Seven Human Cancer Cell Lines  


Abstract Category: Science
Course / Degree: D.Phil BIOCHEMISTRY
Institution / University: ALLAHABAD UNIVERSITY, India
Published in: 2013


Paper Abstract / Summary:

Plant extracts of species of the genus Euphorbia (Euphorbiaceae) used by tradi-tional healers for the treatment of ulcers, cancers, tumors, warts, and other diseases, were tested in vitro for their potential anti-proliferative and cytotoxic activity. The objective of the present study was to evaluate the in-vitro anti- cancer effects of ethanolic extract of Several species viz Ricinus communis Linn, Euphorbia helioscopia, Jatropha curcas of the family Euphorbiaceae against seven human cancer cell lines namely Colon cancer cell line (Colon HT-29, SW-620, SiHa), Liver cancer cell line (Hep-2), Breast cancer cell line (T-47D), Cervix cancer cell line OVCAR-5, Prostrate cancer cell line (PC-3). The SRB assay was used to test cytotoxic activity all the cell line. The activity was evaluated at 100 µg / ml concentration of test material. Jatropa curcas showed 47 % activity against SiHa. The ethanolic fraction of seed part of Ricinus communis showed 41 % activity against Colon 502713 while stem part exhibited maximum activity against SiHa (47 %). The ethanolic extract of Euphorbia helioscopia inhibited the growth of only three cancer cell lines viz Hep-2 T-47D and PC-5.


Paper Keywords/Search Tags:
Plant of Euphorbiacae family, Cytotoxic activity, Ethanolic extract, SRB assay

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Submission Details: Paper Abstract submitted by ekta prakash from India on 09-May-2013 11:22.
Abstract has been viewed 3173 times (since 7 Mar 2010).

ekta prakash Contact Details: Email: ekta_prakash1@hotmail.com Phone: 9451058024



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